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pentobarbital will lessen the level or influence of guanfacine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Potent or reasonable CYP3A4 inducers substantially decrease guanfacine plasma concentrations and elimination 50 %-lifetime.Check Intently (one)pentobarbital will reduce the extent or outcome of e